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Reseña del editor MASTER MODERN MEDICINE!Introducing the Landmark Twentieth Edition of the Global Icon of Internal MedicineThe definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithmsRecognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.Essential for practice and education, the landmark 20th Edition features:Thoroughly revised content?covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine? Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.Important and timely new chapters?such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more?offer the very latest, definitive perspectives on must-know topics in medical education and practice.  Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.End-of-chapter suggested readings reinforc Contraportada 5 STAR REVIEW FROM DOODY’S “This is a book for all students of medicine no matter their level of experience.”'...the leading comprehensive authority in internal medicine.'ReviewerVincent Carr,  DO, MSA, FACC, FACP  (Uniformed Services University of the Health Sciences)DescriptionFor internal medicine specialists, Harrison's has been the go-to reference on the current understanding of pathophysiology for decades. This 20th edition updates the 19th edition published in 2012.PurposeThe purpose remains the same: to provide a comprehensive, up-to-date reference for learners throughout their careers, from medical students through experienced attending physicians and consultants.AudienceThis is a book for all students of medicine no matter their level of experience. The authors have brought together the most knowledgeable and experienced experts to review the latest updates from the journal literature to provide a foundation for the practice of medicine.FeaturesThe book is divided into 20 parts that cover broad topics such as the profession of medicine, cardinal manifestations and presentation of disease, oncology and hematology, immune-mediated, inflammatory, and rheumatological diseases, and disorders associated with environmental exposures. The parts are further divided into specific topic sections, such as pain, therapy for bacterial disease, neurologic critical care. Finally, these sections are subdivided into chapters covering conditions such as urticaria, angioedema, and allergic rhinitis, with lists of further reading suggestions. Throughout the book, there are a great number of full-color figures, algorithms, and intuitive tables to support the text. As readers become familiar with the book's format, it is very easy to use the pertinent patient management algorithm in the front cover page that refers them directly to the relevant page. There is also a listing of available videos; supplemental topics, such as microbial bioterrorism, technique of lumbar puncture; and atlases of rashes, oral manifestations of disease, and electrocardiography. An electronic version of the book is available for separate purchase through the AccessMedicine website, which allows a 30-day trial subscription.AssessmentThis new edition continues the outstanding history of this book as the leading comprehensive authority in internal medicine. Biografía del autor C.F. Kettering Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Molecular Medicine Northwestern University Medical School, Chicago, IL.Anthony S. Fauci, MDChief, Laboratory of ImmunoregulationDirector, National Institute of Allergy and Infectious DiseasesNational Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation's highest civil award.Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of MedicineProfessor of Microbiology and Molecular GeneticsExecutive Dean for Academic ProgramsHarvard Medical SchoolDirector, Channing LaboratoryDepartment of MedicineBrigham and Womens HospitalStephen L. Hauser, MDChairman and Betty Anker Fife ProfessorDepartment of NeurologyUniversity of California, San FranciscoDan L. Longo, MDScientific DirectorNational Institute on AgingNational Institutes of HealthBethesda, Maryland

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